Diversity in genetic risk of recurrent stroke: a genome-wide association study meta-analysis.

ABSTRACT:

Introduction

Stroke is a leading cause of death and disability worldwide. Recurrent strokes are seven times more lethal than initial ones, with 54% leading to long-term disability. Substantial recurrent stroke risk disparities exist among ancestral groups. Notably, Africans face double the risk and higher fatality rates compared to Europeans. Although genetic studies, particularly GWAS, hold promise for uncovering biological insights into recurrent stroke, they remain underexplored. Our study addresses this gap through meta-analyses of recurrent stroke GWAS, considering specific ancestral groups and a combined approach.

Methods

We utilized four independent study cohorts for African, European, and Combined ancestry recurrent stroke GWAS with genotyping, imputation, and strict

SUBMITTER: Aldridge CM 

PROVIDER: S-EPMC12802773 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature