Plasma apolipoprotein E and monocyte chemoattractant protein-1 levels in young people with HIV and ischemic stroke in Lusaka, Zambia.

ABSTRACT:

Background

Apolipoprotein E (ApoE) and monocyte chemoattractant protein-1 (MCP-1) are inflammatory markers associated with premature atherosclerosis, which leads to increased cardiovascular disease risk among people with HIV (PWH). We aimed to evaluate the association between the plasma levels of these inflammatory markers and ischemic stroke in young PWH.

Methods

We conducted a prospective case-control study at the University Teaching Hospital in Lusaka, Zambia, between March 2022 and October 2024, comparing young PWH with non-cardioembolic ischemic stroke (cases) to age- and sex-matched PWH without a history of stroke (controls). Standardized data collection instruments were used to collect information on other known risk factors for stroke, including demographic, clinical

SUBMITTER: Zimba S 

PROVIDER: S-EPMC12802788 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature