Identification of antimicrobial resistance genes in Escherichia coli through network diffusion.

ABSTRACT:

Objectives

Antimicrobial resistance (AMR) is an escalating global health concern, driven by multifactorial biological processes not yet fully understood. This study employed network diffusion analysis to dissect the molecular mechanisms driving AMR in Escherichia coli, aiming to identify novel potential drug targets for therapeutic development.

Methods

A systems biology approach was used to identify genes and biological pathways associated with AMR, by mapping known AMR-related genes from the Comprehensive Antibiotic Resistance Database (CARD) and PointFinder database into the E. coli protein interactome. Through a network diffusion algorithm, several network modules were identified, i.e. genes and pathways, in part already known to be involved in AMR mechanisms. We selected

SUBMITTER: Mansouri A 

PROVIDER: S-EPMC12802890 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature