β-Lactam concentrations monitored in the early phase of community-acquired sepsis in the intensive care unit.

ABSTRACT:

Objectives

Optimal antibiotic treatment is important in the treatment of sepsis. However, patients with sepsis are at risk of suboptimal antibiotic concentrations. This study aimed to evaluate β-lactam antibiotic concentrations during the first 48 h in patients with community-acquired sepsis admitted to the ICU, and to identify variables associated with antibiotic concentrations that were too low or too high.

Methods

This prospective, observational, single-centre study included patients aged ≥18 years with a high likelihood of infection, a SOFA score of ≥2p, planned β-lactam antibiotic treatment, and ICU admission. The exclusion criteria were ongoing antibiotic treatment and/or nosocomial infections. β-Lactam concentrations were measured up to seven times during the first 48

SUBMITTER: Liljedahl Prytz K 

PROVIDER: S-EPMC12802928 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature