(Re)defining the human chromatome: an integrated meta-analysis of localization, function, abundance, physical properties, and domain composition of chromatin proteins.

ABSTRACT: The full complement of chromatin-associated proteins-collectively referred to as the chromatome-enables genome functioning in eukaryotes by participating in a wide range of physico-chemical processes. These include mediating diverse specific and nonspecific intermolecular interactions, catalyzing in situ synthesis and modification of macromolecules, facilitating ATP-dependent chromatin remodeling, etc. Despite considerable progress in epigenomics and the structural characterization of many nuclear proteins and their complexes, our understanding of chromatin organization at the proteome scale remains incomplete. This gap hinders the development of a holistic view of genome regulation. In this study, we present a state-of-the-art characterization of the human chromatome based on an integrati

SUBMITTER: Gribkova AK 

PROVIDER: S-EPMC12802929 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature