Omadacycline as a drug candidate for Mycobacterium avium infections: in vitro insights on single and combination therapies.

ABSTRACT:

Objectives

The current antibiotic arsenal for the treatment of Mycobacterium avium infections is limited and new treatment options are needed. This exploratory study assessed the in vitro activity of omadacycline against M. avium alone and combined with current guideline-recommended antibiotics and the ability of omadacycline to prevent the emergence of antibiotic resistance.

Methods

The activity of omadacycline and comparator antibiotics against M. avium was studied by minimum inhibitory concentration (MIC) assays and time-kill kinetics assays to investigate time- and concentration-dependent activity patterns. Omadacycline's ability to prevent clarithromycin and amikacin resistance was investigated by phenotypic and molecular assays.

Results

The MIC of omadacycline w

SUBMITTER: Mudde SE 

PROVIDER: S-EPMC12802935 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature