β-Lactam dosing in critically ill children: predictors for target non-attainment.

ABSTRACT:

Introduction

β-Lactam antibiotics are among the most frequently prescribed antibiotics on the paediatric ICU (PICU). For β-lactam antibiotics, unbound plasma concentrations above at least one to four times the MIC for 100% of the dosing interval (100% ƒT > 1-4×MIC) have been proposed as the pharmacodynamic target. This study aimed to determine target attainment of β-lactam antibiotics in PICUs and to identify predictors of target non-attainment.

Patients and methods

This prospective observational study was performed in two PICUs in the Netherlands. We enrolled paediatric patients treated with the following β-lactam antibiotics: cefotaxime, ceftazidime, ceftriaxone, cefuroxime, flucloxacillin and meropenem. The free concentration above the bacterial epidemiological cut-off mi

SUBMITTER: Schouwenburg S 

PROVIDER: S-EPMC12802960 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature