Systematic review of antimicrobial pharmacokinetic/pharmacodynamic indices in murine thigh and hollow fibre dose fractionation studies analysed with a standard method.

ABSTRACT:

Background

Pre-clinical models are commonly used to determine human antibiotic dosage regimens using pharmacokinetic/pharmacodynamic (PKPD) indices. The murine thigh infection model (MTIM) is most commonly used for PKPD index determination, while the hollow fibre infection model (HFIM) may be a viable alternative. However, there is no standardized method for determining the PKPD index and R2 may not be the ideal metric to determine goodness of fit for nonlinear models. This study aimed to reanalyse PKPD indices published in MTIM and HFIM, using a standardized modelling approach.

Methods

Systematic literature review was conducted to identify MTIM and HFIM dose fractionation studies. Searches covered databases including PubMed, MEDLINE, BIOSIS, SCOPUS and EMBASE. Data were ext

SUBMITTER: Alabdulkarim N 

PROVIDER: S-EPMC12802965 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature