Sulcal Widening in Schizophrenia Maps onto Sulcal Hubs and Energy-Synaptic Genes.

ABSTRACT: Schizophrenia (SZ) is increasingly framed as a disorder of large-scale brain networks emerging from atypical early neurodevelopment, yet how network architecture relates to cortical folding abnormalities remains unclear. Here, we introduce a sulcal morphological-centred network framework that integrates normative modelling of sulcal width with diffusion-derived structural connectivity and transcriptomic data in a large multisite cohort (n = 5,392; 377 SZ). Individuals with SZ showed widespread sulcal widening, affecting 30 of 40 sulci and most pronounced in frontal, temporal and occipital regions. Critically, sulci with higher degree centrality, reflecting greater embedding within the structural connectome, exhibited disproportionately greater widening in SZ (p _spin = 0.0

SUBMITTER: Gonzalez-Penas J 

PROVIDER: S-EPMC12803032 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature