Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction.

ABSTRACT: Failures in chromosome segregation during meiosis result in aneuploid gametes and are the leading cause of miscarriage. The position and number of crossovers, genetic exchanges between homologous chromosomes, are essential to their accurate disjunction in meiosis. Previous research analyzing nondisjunction of acro- and telocentric chromosomes in human and Drosophila has identified altered positioning and number of crossovers that differs between meiosis I and meiosis II nondisjunction. Limited data from positioning in chromosomes that segregated normally in metacentric trisomies has suggested discrepancies between the behavior of these chromosomes and the acro/telocentrics in nondisjunction, which warrants further investigation. Here, we employ whole-genome sequencing to study spont

SUBMITTER: Turcotte CA 

PROVIDER: S-EPMC12803044 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature