Repeatable, low-drift recordings in behaving non-human primates using flexible microelectrodes.

ABSTRACT: Neurophysiological recordings from non-human primates (NHPs) have traditionally relied on rigid microelectrode arrays made from stainless steel or silicon. While these devices enable high-quality recordings, a fundamental mechanical mismatch between rigid materials and soft brain tissue leads to inflammation, gliosis, and signal instability. In particular, brain micromotion causes continuous drifting of neurons relative to fixed electrodes, compromising single-unit tracking during both chronic and acute recordings. Flexible, penetrating electrodes offer a promising solution, but their adoption in NHPs has been hindered by the technical challenges of delivering ultra-thin polymers through thick dura mater. Here, we demonstrate a comprehensive approach for acute, repeated recordings in awake

SUBMITTER: Woods DP 

PROVIDER: S-EPMC12803063 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature