High-fat diet rewires gut host-microbiota relationship to derive worse outcomes following <i>Clostridioides difficile</i> infection.

ABSTRACT: Clostridioides difficile is a leading cause of hospital-acquired enteric infections, with outcomes ranging from mild diarrhea to life-threatening pseudomembranous colitis and death. Dietary modulations can influence the course of antibiotic-induced C. difficile infection (CDI), and high-fat diets are associated with increased mortality. Here, we profiled host innate immune cells, cecal microbial composition, and the host transcriptome of normal diet (ND) and high-fat diet (HFD)-fed C57BL/6 male and female mice following experimental CDI during the acute and recovery phases. HFD-fed male mice exhibited delayed disease onset but increased mortality following CDI. During acute infection, HFD-fed males showed increased monocyte infiltration and expansion of CD103⁺CD11b

SUBMITTER: Kumar A 

PROVIDER: S-EPMC12803074 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature