Weak pervasive incompatibilities and compensatory adaptation drive hybrid genome evolution in yeast.

ABSTRACT: Species barriers limit gene flow and maintain co-adapted genomes. Interspecific hybridization can break down species barriers to reveal genetic incompatibilities. Although the phenotypic and genomic consequences of hybridization have been extensively studied in many systems, far less is known about the longer-term evolutionary dynamics of highly divergent, mosaic genomes and the extent to which genetic incompatibilities shape their adaptation. In yeast, pre-zygotic barriers are weak but post-zygotic barriers are strong due to mispairing of chromosomes during meiosis. By suppressing anti-recombination genes in meiosis, we generated a panel of 20 haploid recombinant hybrids from a cross between Saccharomyces cerevisiae and its sister species, Saccharomyces paradoxus. Across con

SUBMITTER: Martinez AA 

PROVIDER: S-EPMC12803087 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature