<i>Candida auris</i> can acquire antifungal resistance without selection pressure.

ABSTRACT: The human fungal pathogen Candidozyma auris (formerly Candida auris) can cause prolonged infection outbreaks with high mortality rates in healthcare settings. Treatment failures of patients arise not only from antifungal drug resistance, but also from intra-species variability in pathogenicity as well as induced hypermutation events in response to clinical therapy. Whole genome sequencing was used to identify genetic mutations using the CDC mycoSNPs pipeline. Antifungal susceptibility testing was performed based on Clinical and Laboratory Standards Institute (CLSI) methods. We report here that the interlaboratory exchange of C. auris clinical isolates dried on sterile filter paper, resulted in the emergence of at least three distinct morphotypes following reconstitution. Thes

SUBMITTER: Phan-Canh T 

PROVIDER: S-EPMC12803088 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature