Donor Macrophage Depletion Permits Post-Transplant Tolerance Induction in a Murine Islet Transplant Model.

ABSTRACT: Current strategies for experimental tolerance induction for allogeneic transplantation typically require recipient preparation days to weeks prior to transplantation, making them not applicable to deceased donor transplantation. Developing tolerance strategies feasible for deceased donor transplantation would greatly increase the pool of eligible patients for tolerance induction. Here, we aimed to induce tolerance with post-transplant only interventions in a murine pancreatic islet transplant model. We demonstrated that transplant tolerance induction by recipient infusions of ethylcarbodiimide-treated donor splenocytes (ECDI-SPs) could be reliably delayed to the post-transplant timeframe provided that donor islets were depleted of intra-islet macrophages prior to transplantation. Mechanist

SUBMITTER: Dilts M 

PROVIDER: S-EPMC12803127 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature