A kinome inhibitor screen implicates adhesion and growth factor signaling in cellular recovery after caspase activation.

ABSTRACT: Apoptosis is a common form of regulated cell death and requires cysteine-aspartic proteases called effector caspases. Caspase activation triggers positive feedback, leading to the idea that apoptosis is irreversible. However, we and others have demonstrated that cancer cells can survive effector caspase activation and become more aggressive and drug-resistant as a result. Despite the profound implications of apoptotic reversal, also known as anastasis, for both regenerative medicine and cancer therapy, the molecular pathways that enable cells to survive executioner caspase activation remain largely unmapped. To systematically dissect this phenomenon, we developed a quantitative screening platform that combines inducible caspase activation with kinome-wide pharmacological profiling. This ap

SUBMITTER: Nano M 

PROVIDER: S-EPMC12803139 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature