Host CD59 Potentiates the Type III Secretion System in <i>Yersinia pseudotuberculosis</i>.

ABSTRACT: Type III secretion systems (T3SS) play critical roles in disease for many Gram-negative pathogens. For Yersinia pseudotuberculosis (Yptb), the machinery delivers the Yop bacterial effectors into host cells, misregulating cytoskeletal components and sabotaging immune defenses. Although the structural details of T3SS assembly have been studied extensively, intimate interactions between the T3SS components and the surface of the target host plasma membrane are poorly characterized. A previous RNA interference (RNAi) identified the GPI-linked surface protein CD59 as a critical host component that supports T3SS translocation pore formation and effector movement into the host cytosol. We show here that depletion and increased levels of CD59 reduced Yptb T3SS pore form

SUBMITTER: Davis KJ 

PROVIDER: S-EPMC12803202 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature