Gonadal and sex chromosomal contributions to sex differences in mammalian brain organization.

ABSTRACT: Sex differences in brain development may contribute to well-known sex differences in behavior and neuropsychiatric risk - making it important to comprehensively map and mechanistically annotate normative sex differences in brain organization. Most sex differences in mammalian brain organization have previously been attributed to differential effects of gonadal hormones based on outcomes from rodent endocrine manipulations at canonical subcortical foci of male-biased brain volume. However, a systematic quantification of both gonadal and sex chromosome dosage (SCD) contributions across all regions of sex-biased brain volume has been lacking. Here, using structural neuroimaging scans from wild-type (n=670) and transgenic mice that dissociate gonadal, X-, and Y-chromosome effects (n=181), we s

SUBMITTER: Lerch JP 

PROVIDER: S-EPMC12803231 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature