An extension of the <i>Cx(Co)</i> ^<i>m</i> model of crossover patterning to account for experimental mortality in <i>Drosophila melanogaster</i>.

ABSTRACT: Classic recombination experiments designed to test genetic and environmental treatments do not directly measure crossing-over, instead rates and distribution of meiotic events in F1 meiocytes is inferred from genetic markers in F2 adults. In Drosophila melanogaster females this procedure introduces a substantial "missing data problem" because 75% of meiotic chromatids segregate to polar body nuclei and another 11% are transmitted to inviable F2 zygotes which cannot be scored for recombination. To address these sources of uncertainty and bias we extend the Cx(Co) ^m model of the data-generating process by assuming: 1) programmed double strand breaks occur as a Poisson point process, 2) crossover maturation is a stationary renewal process, 3) chromosome segrega

SUBMITTER: Koury S 

PROVIDER: S-EPMC12803237 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature