ATGL-mediated lipid droplet lipolysis promotes collective migration in Drosophila.

ABSTRACT: While lipid droplets (LDs), dynamic organelles central to lipid and energy homeostasis, are implicated in cancer cell migration, their roles during collective cell migration remain unknown. We use Drosophila border cell migration as an in vivo model of invasive, collective cell migration to dissect the roles of LDs and the conserved LD lipase, Adipose Triglyceride Lipase (ATGL). Border cell LDs undergo dynamic changes and decrease in volume by the end of migration. Loss of ATGL increases LD volume, whereas border cell overexpression depletes LDs. Loss, border cell knockdown or overexpression of ATGL delays migration and blocks delamination. Further, loss of ATGL disrupts border cell mitochondria - it alters morphology, reduces membrane potential and increases reactive oxygen

SUBMITTER: Wipf IJ 

PROVIDER: S-EPMC12803247 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature