Severity-dependent proteomic alterations in the rat hippocampus following pilocarpine-induced status epilepticus.

ABSTRACT: Status epilepticus (SE) is a prolonged seizure state that can induce lasting hippocampal damage and promote the development of spontaneous seizures and cognitive deficits. The severity and duration of SE strongly influence these long-term outcomes; however, many experimental studies rely on behavioral assessments such as the Racine scale, which may not capture subclinical or non-convulsive seizure activity. Consequently, the molecular consequences of lower-severity seizures that do not meet conventional criteria for severe SE, but may nonetheless contribute to epileptogenesis, remain poorly understood. To address this gap, we investigated whether behavioral seizure severity in the pilocarpine model correlates with distinct proteomic alterations in the hippocampus. Seizures were induced in

SUBMITTER: Soni S 

PROVIDER: S-EPMC12803256 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature