Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.

ABSTRACT:

Background

The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder (BD) remains limited.

Aim

To enhance prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes implicated in lithium response and/or BD aetiology.

Methods

We analysed data collected from BD patients who had received lithium treatment for at least six months and participated in the International Consortium on Lithium Genetics (ConLi⁺Gen, N=2,367) study. The ALDA scale was used to assess lithium responsiveness, and treatment outcome was defined as continuous ALDA score (0-10) and categorical outcome (favourable ≥7 vs unfavourable response). PGSs were calculated for 59 phenotype

SUBMITTER: Sharew NT 

PROVIDER: S-EPMC12803305 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature