Ratio-Driven Lipoprotein Mapping Refines Genetic Pathways of Cardiometabolic Risk.

ABSTRACT: Dysregulated blood lipids are a major predictor of cardiovascular events. A recent genome-wide association study (GWAS) with five clinically relevant lipid traits in 1.65 million individuals implicated over 770 genomic regions in regulating blood lipid metabolism. To translate these associations into clinical applications, a functional understanding of their roles in lipoprotein metabolism, transport and remodeling (LPmtr) is required. Here, we report the deep molecular fine-mapping of 554 of these lipid risk loci using 168 lipoprotein-related traits and all possible ratios between them in over 273,000 participants of the UK Biobank. We identified new ratio-based markers of pathways shared by multiple LPmtr genes, such as the linoleic acid fraction of the polyunsaturated fatty acid pool to

SUBMITTER: Suhre K 

PROVIDER: S-EPMC12803353 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature