A novel plasma proteomic signature predicts long-term incident heart failure risk among persons living with HIV.

ABSTRACT:

Background

Persons with HIV (PWH) have an increased risk of heart failure compared with the general population despite effective viral suppression. No methods currently exist to predict heart failure risk in PWH. We sought to develop a proteomics-based risk model of incident heart failure in a longitudinal cohort of PWH in the Veterans Aging Cohort Study Biomarker Cohort.

Methods

We characterized the baseline plasma proteome of 1,398 PWH using the SomaScan 4.0 aptamer-based platform. We incorporated traditional risk factors, HIV-specific variables, and inflammatory/coagulation markers into Cox proportional hazards models of incident heart failure. For protein risk models, we used least absolute shrinkage and selection operator (LASSO) regression with 10-fold cross-validation

SUBMITTER: Shakil SS 

PROVIDER: S-EPMC12803380 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature