Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays.

ABSTRACT: Organophosphate pesticides are a major source of occupational exposure in the United States. Moreover, malathion has been sprayed over major urban populations in an effort to control mosquitoes carrying West Nile virus. Previous research, reviewed by the U.S. Environmental Protection Agency, on the genotoxicity and carcinogenicity of malathion has been inconclusive, although malathion is a known endocrine disruptor. Here, interindividual variations and commonality of gene expression signatures have been studied in normal human mammary epithelial cells from four women undergoing reduction mammoplasty. The cell strains were obtained from the discarded tissues through the Cooperative Human Tissue Network (sponsors: National Cancer Institute and National Disease Research Interchange). Interind

SUBMITTER: Gwinn MR 

PROVIDER: S-EPMC1280347 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature