Afadin sorts different retinal neuron types into accurate cellular layers.

ABSTRACT: Neurons use cell-adhesion molecules (CAMs) to interact with other neurons and the extracellular environment: the combination of CAMs specifies migration patterns, neuronal morphologies, and synaptic connections across diverse neuron types. Yet little is known regarding the intracellular signaling cascade mediating the CAM recognitions at the cell surface across different neuron types. Using mouse genetics and viral labeling, we investigated the neural developmental role of Afadin (Mandai et al., 1997; Takai and Nakanishi, 2003; Takahashi et al., 1999), a cytosolic adapter protein that connects multiple CAM families to intracellular F-actin. We introduced the conditional Afadin mouse mutant (Beaudoin et al., 2012) to an embryonic retinal Cre, Six3^Cre (Oliver et al., 1995;

SUBMITTER: Lum MR 

PROVIDER: S-EPMC12803510 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature