Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity.

ABSTRACT: Tauopathies represent a major class of neurodegenerative disorders associated with intracellular aggregates of the microtubule-associated protein Tau. To identify molecular modulators of Tau toxicity, we used a genetic screen to identify protein chaperones whose RNAi-mediated knockdown could modulate hTau^V337M-induced eye-ommatidial degeneration in Drosophila. This screen identified the Prefoldins Pfdn5 and Pfdn6 as strong modifiers of hTau^V337M cytotoxicity. Consistent with the known function of Pfdn as a cotranslational chaperone for tubulin, Pfdn5 mutants showed substantially reduced levels of tubulin monomer. However, additional microtubule-related functions were indicated by the robust unexpected association of Pfdn5 with axonal microtubules in vivo

SUBMITTER: Bisht A 

PROVIDER: S-EPMC12803513 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature