Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response.

ABSTRACT: Although the classical biological protein cell cycle protein kinase CDK2 has been extensively studied in higher vertebrates, its function in lower vertebrates beyond the regulation of mitosis remains unknown. In this study, we report a distinct mechanism whereby IFN expression is negatively regulated in fish by CDK2. After infection with the spring viremia of carp virus (SVCV), fish CDK2 expression significantly increased in tissues and cells. Moreover, antiviral resistance was improved in cdk2^-/- homozygotes, and the antiviral cytokine interferon (IFN) expression was significantly higher. At the cellular level, CDK2 overexpression reduced IFN expression, while cdk2 knockdown increased the ability of cells to produce IFN. Subsequently, it was discovered that fish C

SUBMITTER: Lu LF 

PROVIDER: S-EPMC12803515 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature