Treatment of Livedoid Vasculopathy with the Janus Kinase Inhibitors: A Case Series.

ABSTRACT:

Introduction

Livedoid vasculopathy (LV) is a rare chronic recurrent occlusive disease characterized by painful ulcers and atrophic porcelain-white scars. Owing to the lack of strict treatment guidelines, the commonly used traditional treatment methods are not effective in some patients. Therefore, there is an urgent need to develop new therapies for LV.

Case presentations

Here we report 4 cases of LV that were successfully treated with the Janus kinase (JAK) inhibitors. The present study revealed a significant improvement in clinical activity and pain relief in patients with LV after the administration of abrocitinib (3 patients) or upadacitinib (1 patient). The median composite clinical score derived from erythema, ulceration, and physician-assessed pain fell from 7.25 ± 0.

SUBMITTER: Zhao G 

PROVIDER: S-EPMC12803528 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature