Microbiome and Metaproteome of Craniofacial Implant Regions in Health and Disease.

ABSTRACT:

Background

Craniofacial defects from cancer surgery led to functional, aesthetic, and psychological challenges. Rehabilitation with craniofacial implants addresses these issues by improving prosthesis retention through osseointegration and providing predictable cosmetic results. However, maintaining a healthy transcutaneous region is essential for implant longevity.

Objective

Evaluation of the microbial community and host response around extraoral implants.

Methods

In an intrasubject control study design, 12 cancer patients who had undergone oculofacial rehabilitation with implant-supported prostheses were included. Biofilm and peri-implant fluid samples were collected from the transcutaneous region of healthy and diseased implants. Microbiome profiling was conducted

SUBMITTER: Cortizo DL 

PROVIDER: S-EPMC12803561 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature