Progression and topographic subtypes of Terrien marginal degeneration.

ABSTRACT:

Purpose

To report long-term outcomes and to search for immunological and genetic risk factors in Terrien marginal degeneration (TMD).

Methods

Retrospective, in part prospective, hospital-based longitudinal follow-up study of 32 eyes of 16 Finnish patients from 2012 to 2023. Median follow-up was 7.3 years (range, 0.3-15.2). Symptoms, best corrected visual acuity, pattern in axial power map, astigmatism, corneal thickness, higher order irregularity, cavities, progression and human leukocyte antigen genes were analysed. In 13 blood samples, 483 corneal and inflammatory disease-related genes were analysed with exome sequencing.

Results

The median age at first examination was 61 years (range, 13-89). Eleven (69%) patients were male, and 13 (81%) had bilateral disease. The

SUBMITTER: Ruutila M 

PROVIDER: S-EPMC12803575 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature