A U-shaped relationship between left ventricular ejection fraction and risk of worsening heart failure.

ABSTRACT:

Aims

Left ventricular ejection fraction (LVEF) is a key measure of cardiac function. While prior studies showed a U-shaped relationship between LVEF and mortality, its association with worsening heart failure (HF) remains unclear. We aimed to evaluate the association between the full spectrum of LVEF and the risk of worsening HF.

Methods and results

We analysed data from 93 694 consecutive participants (median age 62 years [interquartile range: 50-76 years], 51.4% men) undergoing echocardiography at a tertiary medical centre. LVEF, measured by biplane Simpson's method, was categorized into 5% intervals from <20% to ≥70%. The primary outcome was a composite of all-cause mortality or worsening HF, while the secondary outcomes included all-cause mortality, cardiovascular death,

SUBMITTER: Chang HC 

PROVIDER: S-EPMC12803596 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature