Safety and prognostic value of left ventricular endomyocardial biopsy in dilated cardiomyopathy.

ABSTRACT:

Aims

The need to perform endomyocardial biopsy (EMB) in patients with non-ischaemic dilated cardiomyopathies (DCM) is debated. Here we sought to determine the extent of left ventricular collagen volume fraction (LV-CVF) in DCM patients and to evaluate it as a prognostic marker.

Methods and results

In this retrospective longitudinal study, we included 524 patients with suspected DCM who underwent left ventricular EMB (LV-EMB) as a part of their clinical work-up. LV-CVF was quantified using automated image processing of high-resolution scans of LV-EMB. Deep phenotyping was performed including assessment of late gadolinium enhancement on cardiac magnetic resonance imaging. Endpoints were (i) composite endpoint of heart failure-related death, sudden cardiac death, aborted sudden

SUBMITTER: Kayvanpour E 

PROVIDER: S-EPMC12803607 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature