Nanotechnology-Enabled Blood Test for Oral Epithelial Disorders Management: A Proof-of-Concept Study.

ABSTRACT:

Objective

To address the limitations and complexities associated with tissue biopsy, emerging nanotechnology methods show promise in enhancing the detection and management of oral squamous cell carcinoma and oral potential malignant disorders. Among them, the characterization of the protein corona, the biomolecular layer that envelops materials when exposed to biological fluids, has recently emerged as a powerful tool for distinguishing oncological patients from healthy people.

Materials and methods

Building upon recent insights, here we formulated a new diagnostic method for oral squamous cell carcinoma and oral potentially malignant disorders based on the characterization of the personalized protein corona formed on graphene oxide nanosheets when exposed to the plasma of t

SUBMITTER: Quagliarini E 

PROVIDER: S-EPMC12803622 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature