Familial Patterns of Oral-Gut Dysbiosis and Systemic Markers in Periodontitis.

ABSTRACT:

Aim

To investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children.

Methods

Eighty participants were divided into four groups (n = 20): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC). Clinical periodontal parameters were recorded. Saliva and faecal bacterial DNA were analysed via 16S rRNA sequencing. Salivary lactoferrin, faecal calprotectin, gingival crevicular fluid cytokines (IFN-γ, IL-10, IL-17, IL-1β, IL-4, TNF-α) and urinary intestinal permeability markers (claudin-2, -3, -4, haptoglobin) were quantified.

Results

Parents with periodontitis showed distinct faecal microbiota profiles, which were mirrored in their childr

SUBMITTER: Paz HES 

PROVIDER: S-EPMC12803660 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature