The Subgingival Host-Microbial Landscape in Mothers With Periodontitis and Their At-Risk Offspring.

ABSTRACT:

Aim

To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases.

Methods

Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring. Periodontal clinical parameters were assessed. Gingival crevicular fluid (GCF) and subgingival biofilm were collected from the same sites. Proteome from GCF was investigated by liquid chromatography-tandem mass spectrometry with data-independent acquisition (DIA-PASEF). Bacterial DNA from subgingival biofilms was sequenced using the 16S rRNA gene for taxonomy assignment.

Results

Overall, 6147 bacterial and human proteins (≥ 2 peptides) were quant

SUBMITTER: Paz HES 

PROVIDER: S-EPMC12803676 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature