Impact of anti-VEGF therapy versus laser therapy on mortality and treatment outcomes in retinopathy of prematurity: A systematic review and meta-analysis.

ABSTRACT:

Purpose

Retinopathy of prematurity (ROP) is a major cause of childhood blindness, and selecting the optimal treatment between anti-vascular endothelial growth factor (anti-VEGF) and laser therapy is crucial. Understanding their impact on key outcomes, particularly mortality, is essential for informed clinical decision-making.

Methods

A systematic literature search identified published studies comparing anti-VEGF and laser therapy for ROP up to December 31, 2024. Primary outcomes included mortality, retinal detachment, surgical interventions, myopia and neurodevelopmental outcomes. The risk of bias was assessed using the Cochrane Risk of Bias Tool and ROBINS-I. Data were synthesized using a random-effects model, with risk ratios (RR) and 95% confidence interval (CI). This rev

SUBMITTER: Wang WD 

PROVIDER: S-EPMC12803688 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature