Increased insular functional connectivity during repetitive negative thinking in major depression and healthy volunteers.

ABSTRACT:

Background

Repetitive negative thinking (RNT) in major depressive disorder (MDD) involves a persistent focus on negative self-related experiences. Resting-state fMRI shows that the functional connectivity (FC) between the anterior insula and the superior temporal sulcus is associated with RNT intensity. This study examines how insular FC patterns differ between resting state and RNT induction in MDD and healthy control (HC) participants.

Methods

Forty-one individuals with MDD and 28 HCs (total n = 69) underwent resting-state and RNT-induction fMRI scans. Seed-to-whole brain analysis using insular subregions as seeds was performed.

Results

No diagnosis-by-run interaction effects were observed across insular subregions. MDD participants showed greater FC between

SUBMITTER: Edwards LS 

PROVIDER: S-EPMC12803699 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature