Non-contact optical spectroscopy for metabolic and vascular characterizations of orthotopic tongue cancer models <i>in vivo</i>.

ABSTRACT: Most tissue optical spectroscopy platforms use a fiber probe for light delivery and collection, while the inconsistent probe-sample contact could induce significant distortions in the measured optical signals, which consequently bring analysis errors. Moreover, it will be practically difficult to use a fiber probe for measurements in some cases such as oral cancer investigations using small animal models. To address the critical challenge, we report a portable, lens-based, optical spectroscopy device capable of quantifying key vascular and metabolic parameters in vivo without probe-sample contact. We combined lenses based diffuse reflectance and fluorescence spectroscopy into one portable platform to enable multi-parametric functional characterizations of orthotopic tongue cancer mo

SUBMITTER: Hasan MZ 

PROVIDER: S-EPMC12803724 | biostudies-literature | 2026 Jul-Aug

REPOSITORIES: biostudies-literature