Time Toxicity of Endocrine-based Oral CDK4/6 Inhibitor Therapies.

ABSTRACT: Adjuvant endocrine therapy with CDK4/6 inhibitors necessitates regular visits, lab assessments and side effect management, currently conducted primarily at breast cancer centers in Germany. This retrospective analysis estimates the potential travel distances, times and CO ₂ emissions associated with centralized therapy management of adjuvant CDK 4/6 inhibitor application. Eligible patients for ribociclib or abemaciclib therapy were retrospectively identified from 5053 early breast cancer cases at the university hospitals of Ulm, Lübeck and Tübingen, using the monarchE and NATALEE criteria. Travel times were calculated assuming 24 visits over three years for ribociclib and 18 visits over two years for abemaciclib. Of the HR+/HER2- cohort, 1432 (38%) were potentially eligible for

SUBMITTER: Schaffler H 

PROVIDER: S-EPMC12803762 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature