Trivalent chromium interacts directly with acetylated lysine.

ABSTRACT:

Background

Hexavalent chromium Cr(VI), a well-established human carcinogen, induces systemic toxicity affecting reproductive, neurological, hepatic, and immune systems. The broad spectrum of its toxicity implies mechanisms of action that transcend organ-specific or cell type-restricted pathways. Protein interactions have been proposed as a mechanism underlying Cr(VI) toxicity and carcinogenicity.

Objective and methods

To address gaps in understanding the molecular effect of Cr(VI), particularly the distinct roles of its two stable oxidation states-Cr(VI) and the trivalent form Cr(III) -we employed high-resolution mass spectrometry to identify the protein targets, compare valence-state-specific interactions (Cr(VI) vs. Cr(III)), and map the specific amino acid residues involv

SUBMITTER: Wise RM 

PROVIDER: S-EPMC12803765 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature