Circadian and photoperiodic control of melatonin in <i>Drosophila ananassae</i>.

ABSTRACT: Melatonin is a widely conserved indoleamine with well-established roles in circadian timekeeping, sleep regulation, and physiological coordination across taxa. In Drosophila melanogaster, early studies reported daily melatonin rhythms, but little is known about melatonin dynamics in other Drosophila species. Here, we measured melatonin secretion in >14,000 Drosophila ananassae across 12 circadian timepoints under four simulated photoperiods: LD 8:16 (short day), LD 12:12 (equatorial), LD 16:8 (long day), and LD 20:4 (arctic summer). Using LC-MS/MS detection in pooled whole-fly samples, we identified robust, bimodal melatonin rhythms across all conditions, with conserved peaks at approximately ZT7 and ZT13 irrespective of daylength. Melatonin levels were significantly e

SUBMITTER: Dollish HK 

PROVIDER: S-EPMC12803798 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature