Tailoring nanotopography and antibacterial properties of calcium phosphate bone grafts via fluoride incorporation.

ABSTRACT: Despite advances in bone graft design and surgical techniques, bacterial infection remains a major cause of graft failure, exacerbated by the global rise in antimicrobial resistance. This has intensified the pursuit of antibiotic-free strategies to prevent bacterial colonization. Among these, antibacterial surface nanotopographies have emerged as promising tools, leveraging nanoscale geometries to physically disrupt bacteria upon contact. In this study, we engineered the surface of a calcium phosphate bone graft to confer antimicrobial functionality through a dual approach: the creation of high-aspect-ratio nanotopographies and ionic doping with fluoride. Through controlled hydrolysis of α-tricalcium phosphate by biomimetic and hydrothermal treatments, we generated calcium deficient hydrox

SUBMITTER: Arca-Garcia C 

PROVIDER: S-EPMC12803813 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature