Mineralocorticoid Receptor in Glutamatergic Neurons Modulates Anxiety Exclusively in Male Mice Via Regulation of the Actin-Bundling Factor Fam107a.

ABSTRACT:

Background

Exposure to stressful life events is a major risk factor for many psychiatric disorders. The mineralocorticoid receptor (MR) is a key regulator of the hypothalamic-pituitary-adrenal axis, a central stress response component. Stress-related mental disorders, such as anxiety and depression, are associated with MR dysfunction in the brain, but its cell type-specific contributions to emotional behavior and cognitive function remain unclear.

Methods

Using a mouse model with a specific deletion of MR in forebrain glutamatergic neurons, we tested the behavioral, structural, and functional impact of MR in this neuronal population (n = 9-14 for behavioral and n = 3-4 for structural and functional analyses).

Results

We revealed a specific function of MR

SUBMITTER: Yang H 

PROVIDER: S-EPMC12803904 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature