BK virus kinetics and associated cystitis/urethritis symptoms after PTCy-based allogeneic hematopoietic cell transplant.

ABSTRACT:

Abstract

BK virus-associated cystitis/urethritis (BK-C) is a major cause of morbidity in allogeneic hematopoietic cell transplant (HCT) recipients. We prospectively followed weekly plasma and urine BK viral loads and associated symptoms in 169 recipients of posttransplant cyclophosphamide (PTCy)-based HCT. Patients with ≥2 positive BK specimens before day +100 were considered at-risk for developing BK-C. Many patients had detectable BK viruria already before the start of conditioning (40%) and HCT (51%), whereas baseline detectable BK viremia was less common (8% and 11%, respectively). Of 169 patients, 133 (79%) were at risk for BK-C: of these, 96 (72%) developed BK-C after a median 30 days after HCT, which lasted a median 26 days; 76 (79%) had macroscopic hematuria. BK viral level

SUBMITTER: Dimitrova D 

PROVIDER: S-EPMC12803918 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature