The Effect of Optic Nerve Crush on Lens-Induced Myopia in Mice.

ABSTRACT:

Objective

The underlying mechanism of refractive development-whether it is confined to the local eyeball or involves the central visual pathways-remains controversial. This study aimed to explore the effect of optic nerve crush (ONC) on refractive development and lens-induced myopia (LIM) in mice and its potential mechanism.

Design

Laboratory experimental study.

Subjects

Three-week-old C57BL/6 mice were used in this study. The animals were divided into the following experimental groups: ONC group versus sham surgery (SHAM) group; ONC combined with LIM (ONC-LIM) group versus SHAM combined with LIM (SHAM-LIM) group; LIM followed by ONC group verus LIM group versus plano lens group.

Methods

The refraction and ocular biological parameters were measured. Bulk RNA-se

SUBMITTER: Tang XH 

PROVIDER: S-EPMC12803928 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature