Intensity-modulated proton therapy vs intensity-modulated radiotherapy in nasopharyngeal carcinoma: a case-control study.

ABSTRACT:

Background

Intensity-modulated proton therapy (IMPT) is associated with fewer acute toxicities compared with intensity-modulated radiotherapy (IMRT) in definitive treatment of nonmetastatic nasopharyngeal carcinoma (NPC). Longer term efficacy and safety data are warranted to appraise the comparative benefit of IMPT for this population. The aim of this study was to evaluate the long-term toxicity and survival outcomes of NPC treated with IMPT vs IMRT at a tertiary academic cancer center during 2016-2022.

Methods

Sixty-seven (42.1%) cases treated by IMPT, and 92 (57.9%) controls treated by IMRT were included.

Findings

The median follow-up time was 55.4 months (interquartile range [IQR], 32.1-73.8 months). The incidence of any grade 2+ acute toxicity was lower with IMPT

SUBMITTER: Cao C 

PROVIDER: S-EPMC12803946 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature