A large puncture closer of aortic wall by multi-memory actions with thrombo-hemodynamic control.

ABSTRACT: The vascular wall regulates the pattern and pressure of blood flow. In cardiovascular interventions, catheters are deployed by puncturing the vessel wall, without exception. Despite continuous progress, the outcomes remain highly operator-dependent, and large punctures with high-pressure bleeding continue to pose clinical challenges. As a translatable solution, this study introduces a shape memory vascular wall plug (VWP) that automates both the Body and Wing functions within a single component, supported by a Ring assembly to maximize pressure resistance. The VWP is deployed into a 6-mm puncture in a porcine thoracic aorta under peak blood pressure, and shape recovery is triggered by a 45°C saline flush to enable automated activation. Upon recovery, Body expansion combined with Ring compr

SUBMITTER: Cho S 

PROVIDER: S-EPMC12803994 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature