Stereotactic Body Radiotherapy vs. Metastasectomy for Soft Tissue and Bone Sarcoma Lung Metastases - A Systematic Review analyzing Safety and Efficacy.

ABSTRACT:

Background

Pulmonary metastases (PM) develop in ∼ 30 % of sarcoma patients after curative therapy and confer poor prognosis. Surgery and stereotactic body radiotherapy (SBRT) are viable local ablative options, but direct comparative data is limited. This systematic review evaluates oncologic outcomes and toxicities of surgery versus SBRT for sarcoma-derived PM.

Materials and methods

We systematically reviewed Medline and references for studies of sarcoma-PM treated with surgery or SBRT according to PRISMA, including publications up to 13th May 2025. Outcomes included local control (LC), progression-/disease-free survival (PFS/DFS), overall survival (OS), and toxicities, with OS data harmonized for pooled analysis.

Results

Fifty-eight mostly retrospective studies compr

SUBMITTER: Kretzschmar L 

PROVIDER: S-EPMC12804006 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature