Repulsions instruct synaptic partner matching in an olfactory circuit.

ABSTRACT: Neurons exhibit extraordinary precision in selecting synaptic partners. Although cell-surface proteins (CSPs) that mediate attractive interactions between developing axons and dendrites have been shown to instruct synaptic partner matching^1,2, the degree to which repulsive interactions have a role is less clear. Here, using a genetic screen guided by single-cell transcriptomes^3,4, we identified three CSP pairs, Toll2-Ptp10D, Fili-Kek1 and Hbs/Sns-Kirre, that mediate repulsive interactions between non-partner olfactory receptor neuron (ORN) axons and projection neuron (PN) dendrites in the developing Drosophila olfactory circuit. Each CSP pair exhibits inverse expression patterns in the select ORN-PN partners. Loss of each CSP in ORNs led to similar synaptic partner ma

SUBMITTER: Li Z 

PROVIDER: S-EPMC12804089 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature